According to findings published by clinical endocrinology. High level of endogenous melatonin is associated with lower risk in the development of type 2 diabetes in both adults and older men who are diabetic. Finnish adults newly diagnosed with diabetes are more likely to die of suicide, accidents and alcohol-related causes, suggesting a need for increased psychological and social support following disease diagnosis, according to findings from a registry-based study. Also, women secreting low levels of melatonin are more likely to develop type 2 diabetes than those who have higher levels of this hormone from a new observational research.
There is a rising evidence suggesting a link between disturbances in melatonin and impaired insulin. Melatonin influence insulin secretion both in vitro and vivo. During night time the level of melatonin level is related to night time insulin concentration in diabetic patients.
According to findings, obesity and weight change may also predict the trajectory of childhood sleep-disordered breathing, early engagement and intervention are important for children diagnosed with type 2 diabetes and metformin is ineffective for long-term metabolic improvements in teen obesity.
Children with obesity and sleep-disordered breathing are more likely to have persistent sleep conditions into adolescence vs. children without obesity, whereas children who lose weight are more likely to experience remission of sleep-disordered breathing symptoms, according to study findings published in Pediatric Obesity. Read more.
Early engagement, intervention ‘crucial’ for children diagnosed with type 2 diabetes. Children newly diagnosed with type 2 diabetes are at high risk for disease-related complications, including a fourfold increase in microalbuminuria over 1 year; however, weight loss and taking medications as prescribed can improve long-term outcomes, according to findings published in Pediatric Diabetes.
Adolescents with obesity assigned to long-term metformin therapy experienced initial improvements in BMI and insulin resistance that were not sustained after 3 years, according to findings published in Nutrition & Diabetes.
Recent studies show that a single nucleotide polymorphism of the human melatonin receptor 1B has been linked with an increased risk in development of diabetes type 2.This data suggest that endogenous and exogenous melatonin play a role in diabetes and associated metabolic disturbances not only by regulating insulin secretion and providing protection against reactive oxygen species, pancreatic B-cell are susceptible to oxidative stress because they possess only low anti-oxidative capacity.